sayaph1 Fundamentals Explained

Yeast cells are beneficial to display screen for mutations that control γ-secretase activity. inside the current examine, we identified Aph1 mutants that possess protease activity during the absence of NCT. We discovered that these mutants enhanced γ-secretase endoproteolysis activity with whole subunits. We propose that the underlying mutations trigger conformational changes in PS1 to reinforce protease action.

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